Clinical Evidence

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Clinical Data

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General Overview of xx

Melatonin in Humans

The New England Journal of Medicine, 1997.

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Sleep-Inducing Effects of Melatonin

Sleep-Inducing Effects of Low Doses of Melatonin Ingested in the Evenings

(Harvard Medical School and MIT) Clinical Pharmacology & Therapeutics, 1995.

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Effects of Exogenous Melatonin on Sleep: A Meta-Analysis

(MIT, Boston University School of Medicine, University of Glasgow, UK, and Hadassah Medical Center, Israel) Sleep Medicine Reviews, 2005.

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Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders

(Yale University, Children’s Hospital of Michigan, and University of São Paulo Medical School) PLOS One, 2013.

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Prolonged-Release Melatonin

Prolonged-Release Melatonin Improves Sleep Quality and Morning Alertness in Insomnia Patients Aged 55 Years and Older and Has No Withdrawal Effects

(The Clinique Lyon-Lumière, France; Neurim Pharmaceuticals, Israel; Tel Aviv University, Israel) Journal of Sleep Research, 2007.

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Prolonged-Release Melatonin for Insomnia – An Open-Label Long-Term Study of Efficacy, Safety, and Withdrawal

(The Clinique Lyon- Lumière, France; Shoham Geriatric Medical Center, Israel; Neurim Pharmaceuticals, Israel; Tel Aviv University, Israel) Therapeutics and Clinical Risk Management, 2011.

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Safety